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Adriaan A van Bodegraven Selected Research

Thioguanine (Tioguanine)

6/2019Limited relevance and progression of histological alterations in the liver during thioguanine therapy in inflammatory bowel disease patients.
1/2019Sustained effectiveness, safety and therapeutic drug monitoring of tioguanine in a cohort of 274 IBD patients intolerant for conventional therapies.
11/2018Nonsynonymous Polymorphism in Guanine Monophosphate Synthetase Is a Risk Factor for Unfavorable Thiopurine Metabolite Ratios in Patients With Inflammatory Bowel Disease.
4/2018Thiopurines in Inflammatory Bowel Disease: New Findings and Perspectives.
1/2018Methotrexate and Thioguanine Rescue Therapy for Conventional Thiopurine Failing Ulcerative Colitis Patients: A Multi-center Database Study on Tolerability and Effectiveness.
1/2018Finding hidden treasures in old drugs: the challenges and importance of licensing generics.
1/2017Nodular Regenerative Hyperplasia of the Liver in Patients with IBD Treated with Allopurinol-Thiopurine Combination Therapy.
10/2016Efficacy of thioguanine treatment in inflammatory bowel disease: A systematic review.
2/2016Safety of Tioguanine During Pregnancy in Inflammatory Bowel Disease.
12/2007Drug Insight: pharmacology and toxicity of thiopurine therapy in patients with IBD.

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Adriaan A van Bodegraven Research Topics

Disease

27Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
01/2022 - 12/2007
8Ulcerative Colitis
05/2022 - 07/2005
8Crohn Disease (Crohn's Disease)
05/2019 - 06/2013
4Colitis
05/2022 - 01/2011
4Hyperplasia
06/2019 - 12/2007
3Inflammation (Inflammations)
01/2022 - 01/2011
3Colorectal Neoplasms (Colorectal Cancer)
10/2021 - 03/2014
3Neoplasms (Cancer)
01/2018 - 08/2013
3Adenoma (Adenomas)
07/2014 - 04/2013
2Necrosis
01/2018 - 07/2017
2Celiac Disease (Celiac Sprue)
06/2014 - 12/2006
2Pancytopenia
03/2014 - 06/2008
2Infections
06/2013 - 06/2008
1COVID-19
04/2021
1Portal Hypertension
01/2019
1Genetic Predisposition to Disease (Genetic Predisposition)
01/2018
1Leukopenia
06/2017
1Anemia
06/2017
1Thrombocytopenia (Thrombopenia)
06/2017
1Constipation
01/2016
1Intestinal Diseases (Diseases, Intestinal)
09/2014
1Gastrointestinal Diseases (Functional Gastrointestinal Disorders)
07/2014
1Pre-Eclampsia (Preeclampsia)
03/2014
1Melanoma (Melanoma, Malignant)
08/2013
1Weight Loss (Weight Reduction)
05/2011
1Pneumonia (Pneumonitis)
06/2008
1Autoimmune Diseases (Autoimmune Disease)
06/2006
1Hemorrhage
01/2006
1Pouchitis
07/2005

Drug/Important Bio-Agent (IBA)

222-mercaptopurineIBA
01/2022 - 06/2006
11Azathioprine (Imuran)FDA LinkGeneric
01/2022 - 06/2006
10Thioguanine (Tioguanine)FDA Link
06/2019 - 12/2007
9Mercaptopurine (6 Mercaptopurine)FDA LinkGeneric
01/2022 - 12/2007
7Pharmaceutical PreparationsIBA
12/2021 - 06/2013
5Adrenal Cortex Hormones (Corticosteroids)IBA
05/2022 - 08/2013
5Allopurinol (Remid)FDA LinkGeneric
11/2017 - 12/2011
3Methotrexate (Mexate)FDA LinkGeneric
05/2019 - 06/2013
3Immunosuppressive Agents (Immunosuppressants)IBA
07/2017 - 05/2011
3Biomarkers (Surrogate Marker)IBA
10/2016 - 03/2014
3Volatile Organic CompoundsIBA
09/2014 - 03/2014
2vedolizumabIBA
05/2022 - 05/2019
2Janus Kinase InhibitorsIBA
05/2022 - 01/2020
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
05/2022 - 08/2013
2Leukocyte L1 Antigen Complex (Calgranulin)IBA
05/2022 - 01/2020
2tofacitinibIBA
05/2022 - 01/2020
2NucleotidesIBA
11/2018 - 12/2007
2Infliximab (Remicade)FDA Link
08/2013 - 07/2013
1C-Reactive ProteinIBA
05/2022
1Interleukin-6 (Interleukin 6)IBA
01/2022
1Nitroso CompoundsIBA
10/2021
1LipidsIBA
01/2020
1Ustekinumab (CNTO 1275)FDA Link
05/2019
1Matrix Metalloproteinases (MMPs)IBA
11/2018
1GuanineIBA
11/2018
16-methylthiopurineIBA
11/2018
1Ligases (Synthetase)IBA
11/2018
1Immunomodulating AgentsIBA
04/2018
1Hemoglobins (Hemoglobin)IBA
06/2017
1Monomeric GTP-Binding ProteinsIBA
12/2016
1Carrier Proteins (Binding Protein)IBA
12/2016
1Proteins (Proteins, Gene)FDA Link
12/2016
1triphosphoric acid (triphosphate)IBA
12/2016
1Essential DrugsIBA
11/2016
1Adalimumab (Humira)FDA Link
08/2014
1Immunoglobulin A (IgA)IBA
06/2014
1AntibodiesIBA
06/2014
1Alkaline PhosphataseIBA
03/2014
1IpilimumabIBA
08/2013
1Monoclonal AntibodiesIBA
08/2013
1Hypoxanthine Phosphoribosyltransferase (Hypoxanthine Guanine Phosphoribosyltransferase)IBA
12/2011
1Dextrans (Dextran)FDA Link
05/2011
1SodiumIBA
05/2011
1Messenger RNA (mRNA)IBA
01/2011
1Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
01/2011
1Bile Acids and Salts (Bile Acids)IBA
01/2011
1thiopurine methyltransferase (thiopurine S-methyltransferase)IBA
06/2008
1myosin IXBIBA
12/2006
1Capsules (Microcapsules)IBA
01/2006

Therapy/Procedure

28Therapeutics
01/2022 - 12/2007
3Electronic Nose
09/2014 - 03/2014
2Drug Therapy (Chemotherapy)
01/2018 - 01/2018
1Artificial Respiration (Mechanical Ventilation)
04/2021
1Duration of Therapy
01/2019
1Precision Medicine
01/2018
1Immunomodulation
01/2017
1Gluten-Free Diet
06/2014
1Restorative Proctocolectomy
07/2005